9 Common Pyroluria Symptoms

by Greg Newson

9 Common Pyroluria Symptoms | Conquering Pyroluria

Common Pyroluria Symptoms

Many people when researching Pyroluria or Pyrrole Disorder are confused and often overwhelmed by the number of possible symptoms associated with the condition. To make it easier, we have listed the nine most common Pyroluria symptoms and Pyrrole Disorder symptoms that we have encountered in our clinic. Please note there are links to the complete list of Pyroluria symptoms, towards the end of this blog.

Before we go ahead and name our top 9, it's important to understand why there are many potential symptoms associated with Pyroluria and Pyrrole Disorder. The roles of Zinc, Vitamin B6 and Biotin are vast and a deficiency can affect any organ or body system, resulting in a symptom or disease. The body's reliance on these nutrients, makes it surprising that there are not more symptoms associated with Pyroluria and Pyrrole Disorder.

Zinc is paramount for proper functioning of the immune, nervous and sexual systems and is involved in over 300 chemical reactions within the body.

Vitamin B6 is essential for the proper functioning of the nervous, cardiovascular and immune systems as well as being a catalyst in over 100 enzyme reactions.

Biotin is of extreme importance for the nervous and digestive systems. It is necessary for the manufacture of fatty acids, the breakdown and utilisation of amino acids and the production of glucose from non-carbohydrate foods.

The 9 Most Common Pyroluria Symptoms


Depression is commonly associated with Pyroluria. Serotonin, the body’s happy, feel-good brain chemical, is reliant on Zinc and Vitamin B6, which help convert the essential amino acid tryptophan into serotonin. Unfortunately, low levels of Zinc and Vitamin B6 produce insufficient amounts of serotonin, resulting in smaller amounts of the happy brain chemical, which leads to a person to feeling down and ultimately depressed.

Anxiety and Panic Disorders

Anxiety and Panic Disorders are more commonly associated with low GABA levels. GABA is the body's major relaxing and tranquillising neurotransmitter and acts as the braking system for the body's excitatory brain chemicals. Without the braking action of GABA, a person feels as though they are going a hundred miles an hour and their brain can't slow down. Zinc and Vitamin B6 are required to convert the body's primary excitatory neurotransmitter Glutamate into GABA. If the process doesn't occur effectively, then a person becomes more prone to nervousness, anxiety, panic attacks, racing mind, insomnia, convulsions and Tourette's Syndrome.


To initiate and maintain sleep, melatonin is required. However, melatonin is manufactured from serotonin, which we know from Pyroluria Symptom number 1 requires Zinc and Vitamin B6. While melatonin is essential to promote and maintain sleep, GABA is critical to prevent night-time waking and improves the ability to fall back to sleep quickly.

Stretch Marks

Stretch marks are considered typical in people that grow too quickly in one direction, i.e. upwards or sideways. Unfortunately, stretch marks are a common symptom of Zinc and Vitamin C deficiency and can easily be prevented with proper nutrition and the correct Pyroluria Treatment.

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White Spots on Nails

White spots on the fingernails are another common sign that the body is severely deficient in Zinc. Along with stretch marks, white spots on the nails are one of the two visual signs that Pyroluria or Pyrrole Disorder may be an underlying cause of a person's health condition.

Reoccurring Infections

Zinc is the commander and chief of the immune system. It is present in every white blood cell, in stomach acid, on every mucous membrane (internal body cavity) and the skin. It is our first line of defence against bacteria or pathogenic infection. Low Zinc equates to a weakened immune defence system, which allows invading pathogens to take hold and infect the body.

Hypo-Pigmentation Of The Skin

Hypo-pigmentation of the skin is a condition in which the normal colour of the skin becomes paler than the surrounding skin. Melanin is the substance that browns the skin, but it is very susceptible to hydrogen peroxide, a free radical. The antioxidant enzyme Catalase, which is dependant on Zinc and Vitamin B6 eliminates Hydrogen Peroxide from the body.  Catalase is often deficient in Pyroluria sufferers, and its deficiency is also associated with early greying of the hair.

Low Libido

Testosterone is essential in both men and women to maintain sex drive, and yes you guessed it, Zinc is critical to the manufacture of testosterone. Interestingly, oysters are the highest know source of Zinc and often referred to as an aphrodisiac.

Mood Swings

Vitamin B6 and Zinc have a calming effect on the brain due to their varied roles in the production of the neurotransmitters GABA, Serotonin and Dopamine. Studies have shown that mood swings, agitation and mental health disorders are more prevalent in nutrient deficient individuals. Including an individual who is lacking in Zinc, Vitamin B6 and Biotin.

Complete List Of Pyroluria Symptoms

There are many signs and symptoms associated with Pyoluria and Pyrrole Disorder and they can vary from person to person, depending on their constitution. It is important not to rely on the list of Pyroluria symptoms as a diagnosis for Pyroluria or Pyrrole Disorder. They are an indication that Pyroluria and Pyrrole Disorder may be a cause of a person's health problems, but not a definitive diagnosis. Relying on symptoms alone can result in an expensive waste of money on supplements that overload the body and have the potential to harm. Pyroluria symptoms may be a result of a deficiency in Zinc, a poor diet, or malabsorption. The only way to be 100% sure that Pyroluria and Pyrrole Disorder are the cause of a person's poor health is to Test for the condition.

We have available a free downloadable PDF with an extensive list of potential Pyroluria Symptoms and a list of possible body signs associated with Pyroluria and Pyrrole Disorder.

The information provided here is of a general nature and intended for educational purposes only. We make no claims to diagnose, treat, prevent, alleviate or cure illnesses or diseases with any information or product stated. With any health issue, we suggest you consult your healthcare professional before undertaking any health treatment.

I hope you found this blog useful and if you did, please leave a comment or share on social media.

Thanks and have a great day.

Greg Newson
Greg Newson


Greg is a Naturopathic Doctor and Clinical Herbalist. He is passionate about educating people on all matters of health. Qualifications: B.Sc Health Science, Adv. Dip Naturopathy, Adv. Dip Herbal Medicine, Adv. Dip Nutrition, Dip Remedial Massage

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