Pyrrole Disorder also known as Pyroluria is a genetic or lifestyle generated condition in which the sufferer has a reduced ability to uptake or utilize Vitamin B6, Zinc and Biotin.
Pyrrole Disorder is often described as the abnormal synthesis and metabolism of heme molecules, in particular hemoglobin. All cells in the body uptake nutrients and produce waste. The waste produced by the heme molecules is the metabolite hydroxyhemopyrrolin-2-one (HPL). This metabolite is elevated in Pyrrole Disorder Sufferers and is what binds to Zinc, Vitamin B6 and Biotin and enhancing their urinary excretion.
Supplementation helps to lower HPL levels and reduce the severity of the signs and symptoms often associated with Pyrrole Disorder.
On first glance it may seem that there are a lot of signs and symptoms associated with Pyrrole Disorder. This is mainly due to the diverse roles that Zinc, Vitamin B6 and Biotin have within the body and with cellular function. For example Zinc is involved in over 300 chemical reactions playing a major role in healthy immune, brain, metabolic and nervous system function.
Below is a short list of signs and symptoms associated with Pyrrole Disorder
|Anxiety||Intolerance to alcohol / drugs|
|Constipation||Loss of appetite|
|Early greying of hair||Reading difficulties|
For a full list of signs and symptoms associated with Pyrrole Disorder Please click here
For some sufferers of Pyrrole Disorder they may have abnormalities in their physical appearance. Some of the more common physical appearances associated with Pyrrole Disorder are;
|Acne||Overcrowding of teeth|
|Dry Skin||Poor wound healing|
|Hypo-pigmentation of skin||Skin appears paper thin|
|Inability of skin to tan||Stretch marks|
|Lack of hair on eyebrows or eyelashes||White spots on fingernails|
For a full list of unusual body appearances associated with Pyrrole Disorder Please click here.
There are some common health conditions that have been studied and shown to have a strong relationship with Pyrrole Disorder. Below is a list of these studied health conditions and percentages of those sufferers with Pyrrole Disorder.
|Acute Intermittent Porphyria||100%||Down Syndrome||71%|
|Asperger’s Syndrome||46-48%||Latent Acute Intermittent Porphyria||70%|
Violent / Criminal Offenders
For a full list of health conditions associated with Pyrrole Disorder Please click here
There is evidence suggesting that for some Pyrrole Disorder sufferers that is a genetic connection. Research and statistics indicate that if a parent, brother or sister, grandparent, aunt, or uncle suffers from Major Depression, Bi-Polar Disorder, Schizophrenia, Alcoholism, or has Suicide, that there is a greater risk of Pyrrole Disorder in other family members.
Studies also indicate that Lifestyle Factors play a role in driving up HPL levels, thus contributing to Pyrrole Disorder.
HPL can potentially do a great deal of harm to cells besides contributing to Pyrrole Disorder.
The information provided here is of a general nature intended for educational purposes only. We make no claims to diagnose, treat, prevent, alleviate or cure illnesses or diseases with any information or product stated. With any health issue we suggest you consult your healthcare professional before undertaking any health treatment.
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