People can be a little confused, not only with the pronunciation of Pyroluria, but with the many different names it goes by - Pyrrole Disorder, Kryptopyrrole, Kryptopyrroluria, Mauve Factor and Hemepyrrole to name a few. Regardless of the name or pronunciation, the condition and symptoms are the same.
There seems to be a bit of mystery surrounding exactly what Pyroluria is. Some people believe that it's a severe deficiency of Vitamin B6 and Zinc, while others speculate that it's a bacterial infection, some fall back on "it's a genetic defect" and others just fantasize that it's a make-believe disease.
What we know is that people who suffer from Pyroluria have elevated urinary levels of hydroxyhemopyrrolin-2-one (HPL). HPL is the by-product of heme molecules, in particular hemoglobin, which is responsible for transporting oxygen throughout the body.
It is believed that HPL has the ability to interrupt messages being sent along the neuronal pathways. Resulting in neurological conditions such as depression, schizophrenia, bi-polar disorder and anxiety all, of which can be associated with Pyroluria.
Interestingly HPL falls into the same class as Batrachotoxin, a potent neuro and cardiotoxin found in various animal species, that damages nerve and brain tissue.
Nutritional deficiencies especially Zinc, Vitamin B6 and Biotin are commonly found in Pyroluria Sufferers. What occurs is that HPL binds to and increases the urinary excretion of these nutrients, thus rendering the unavailable and resulting in various signs and symptoms. Supplementing these nutrients is an essential first step in reducing these deficiencies as well as overcoming Pyroluria and its associated symptoms.
Gamma Linolenic Acid (GLA) levels are also compromised in Pyroluria Sufferers as Zinc and Vitamin B6 are essential to upregulating Delta-6-Desaturase, the enzyme responsible for converting the fat found in vegetable seeds and nuts, Linoleic Acid to GLA.
For a Free List of Foods High in Zinc, Vitamin B6 and Biotin please click here.
The causative and driving factors that exacerbate Pyroluria vary from person to person. What we have found through clinical practice is that Pyroluria falls into one of two categories. Its either;
Regardless of what type of Pyroluria people suffer from, the underlying factors that cause, drive or worsen Pyroluria, are the same.
|Chemical Exposure||Prescription Medication|
|Cigarette Exposure||Poor Diet|
|Dysbiosis / Candida||Poor Digestive Health|
|Heavy Metal Exposure||Recreational Drugs|
|Leaky Gut Syndrome||Stress|
Reducing exposure to chemicals, improving the diet and repairing conditions like Leaky Gut Syndrome goes a long way in reversing Pyroluria for many sufferers
The conditions and figures listed below indicate the percentage values from scientific studies, in which participants had high HPL levels
|Acute Intermittent Porphyria - 100%||Epilepsy - up to 44%|
|ADD/ADHD - up to 47%||Learning Difficulties - up to 47%|
|Alcoholism - up to 84%||Manic Depression - up to 50%|
|Allergies||Neurosis/Neurotic - up to 20%|
|Asperger's Syndrome||Post Natal Depression|
|Autism - up to 48%||Schizophrenia Acute - up to 80%|
|Bi-Polar Disorder||Schizophrenia Chronic - up to 50%|
|Criminal Behavior - up to 71%||Substance Abuse|
|Depression - up to 46%||Tourettes Syndrome|
|Down Syndrome - up to 71%||Violent Offenders - up to 71%.|
I hope you found this blog useful and informative. If so please leave a comment or help others by sharing on social media.
Comments will be approved before showing up.