What Is Pyroluria?

by Greg Newson

Understanding Pyroluria

People can be a little confused, not only with the pronunciation of Pyroluria, but with the many different names it goes by - Pyrrole Disorder, Kryptopyrrole, Kryptopyrroluria, Mauve Factor and Hemepyrrole to name a few. Regardless of the name or pronunciation, the condition and symptoms are the same.

So, What is Pyroluria?

There seems to be a bit of mystery surrounding exactly what Pyroluria is. Some people believe that it's a severe deficiency of Vitamin B6 and Zinc, while others speculate that it's a bacterial infection, some fall back on "it's a genetic defect" and others just fantasize that it's a make-believe disease.

What we know is that people who suffer from Pyroluria have elevated urinary levels of hydroxyhemopyrrolin-2-one (HPL). HPL is the by-product of heme molecules, in particular hemoglobin, which is responsible for transporting oxygen throughout the body.

It is believed that HPL has the ability to interrupt messages being sent along the neuronal pathways. Resulting in neurological conditions such as depression, schizophrenia, bi-polar disorder and anxiety all, of which can be associated with Pyroluria.

Interestingly HPL falls into the same class as Batrachotoxin, a potent neuro and cardiotoxin found in various animal species, that damages nerve and brain tissue.

Pyroluria and Nutritional Deficiencies

Nutritional deficiencies especially Zinc, Vitamin B6 and Biotin are commonly found in Pyroluria Sufferers. What occurs is that HPL binds to and increases the urinary excretion of these nutrients, thus rendering the unavailable and resulting in various signs and symptoms. Supplementing these nutrients is an essential first step in reducing these deficiencies as well as overcoming Pyroluria and its associated symptoms.

Gamma Linolenic Acid (GLA) levels are also compromised in Pyroluria Sufferers as Zinc and Vitamin B6 are essential to upregulating Delta-6-Desaturase, the enzyme responsible for converting the fat found in vegetable seeds and nuts, Linoleic Acid to GLA.

For a Free List of Foods High in Zinc, Vitamin B6 and Biotin please click here.

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What causes Pyroluria?

The causative and driving factors that exacerbate Pyroluria vary from person to person. What we have found through clinical practice is that Pyroluria falls into one of two categories. Its either;

  • Genetic, meaning that it runs in the family, or
  • Lifestyle Generated

Regardless of what type of Pyroluria people suffer from, the underlying factors that cause, drive or worsen Pyroluria, are the same.

Alcohol Oxidative Stress
Chemical Exposure Prescription Medication
Cigarette Exposure Poor Diet
Dysbiosis / Candida Poor Digestive Health
Heavy Metal Exposure Recreational Drugs
Leaky Gut Syndrome Stress

Reducing exposure to chemicals, improving the diet and repairing conditions like Leaky Gut Syndrome goes a long way in reversing Pyroluria for many sufferers

Conditions associated with Pyroluria

The conditions and figures listed below indicate the percentage values from scientific studies, in which participants had high HPL levels

Acute Intermittent Porphyria - 100% Epilepsy - up to 44%
ADD/ADHD - up to 47% Learning Difficulties - up to 47%
Alcoholism - up to 84% Manic Depression - up to 50%
Allergies Neurosis/Neurotic - up to 20%
Anxiety Panic Attacks
Asperger's Syndrome Post Natal Depression
Autism - up to 48% Schizophrenia Acute - up to 80%
Bi-Polar Disorder Schizophrenia Chronic - up to 50%
Criminal Behavior - up to 71% Substance Abuse
Depression - up to 46% Tourettes Syndrome
Down Syndrome - up to 71% Violent Offenders - up to 71%.

For More Information and blog posts on Pyroluria

How best to Treat Pyroluria

Pyroluria and Candida

Why Test for Pyroluria

I hope you found this blog useful and informative. If so please leave a comment or help others by sharing on social media.

Greg Newson
Greg Newson


Greg is a Naturopathic Doctor and Clinical Herbalist. He is passionate about educating people on all matters of health. Qualifications: B.Sc Health Science, Adv. Dip Naturopathy, Adv. Dip Herbal Medicine, Adv. Dip Nutrition, Dip Remedial Massage

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